Associate Scientist / Scientist I, Immunology and Cell Biology
IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company focused on creating and developing engineered IgM antibodies. IgM antibodies have inherent properties that we believe may enable them to improve upon the efficacy and safety of IgG antibodies in multiple therapeutic applications.
We have created a proprietary IgM antibody technology platform that we believe is particularly well suited for developing T cell engagers, receptor cross-linking agonists, and targeted cytokines. Our lead product candidate, IGM-2323, is a bispecific T cell engaging IgM antibody targeting CD20 and CD3, and we have initiated a Phase 1 clinical trial for the treatment of relapsed/refractory B cell Non-Hodgkin's lymphoma (NHL) patients in 2019. Our second product candidate is IGM-8444, an IgM antibody targeting Death Receptor 5 (DR5) for the treatment of patients with solid and hematologic malignancies, for which we have recently initiated a Phase 1 clinical trial. Also, in our product pipeline is IGM-7354, a bispecific IgM antibody delivering interleukin-15 (IL-15) cytokines to PD-L1 expressing cells for the treatment of patients with solid and hematologic malignancies.
Position Summary:
We are looking for a Temporary Associate Scientist / Scientist I with a background in immunology, oncology, or cell biology to join our growing and friendly team. The ideal candidate will be a highly motivated and creative scientist experienced with cell-based assays and multi-parameter flow cytometry. The candidate will play an integral role in the pre-clinical development of novel oncology/immuno-oncology therapeutics and provide pre-clinical support for our clinical-stage therapeutics.
Requirements:
- Culture cells and perform cell-based assays (eg, cell binding, reporter, viability, CDC, TDCC, internalization assays)
- Perform multi-color flow cytometry
- May perform PBMC assays and cytokine quantitation
- Maintain a detailed and well-organized notebook
Qualifications:
- B.S. or M.S. in Immunology, Cell Biology or related disciplines with 6+ years of industry research experience or Ph.D. with 0-2 years of related industry research or equivalent postdoctoral research experience.
- Proficiency in cell culture and cell-based assays (eg, reporter, viability, CDC, TDCC, internalization assays).
- Experience working with PBMCs and primary immune cell subsets is a plus.
- Experience with multi-color flow cytometry (eg, cell binding, immunophenotyping, proliferation, cytokine quantitation)
- Must be highly organized with reliable time-keeping skills and able to maintain a detailed and well-organized notebook.
- Must be proficient with Microsoft Word, Excel, and PowerPoint, GraphPad Prism and FlowJo.
- Must have good verbal and written communication skills with ability to present data in meetings.
- Must be proactive, persistent, independent and able to interpret results and determine next steps with minimal guidance.
- Must have strong interpersonal and collaboration skills. Being a team player and respectful of others is a must.
- Able to thrive in a fast-paced, start-up environment.
- Able to commute to Mountain View.
- Mountain View, CA 94043: Reliably commute or planning to relocate before starting work (Required)