Research Associate, In Vivo Pharmacology
Company Overview
Avidity Biosciences is pioneering a new class of oligonucleotide-based therapies called AOCs designed to overcome the current limitations of oligonucleotide therapies in order to treat a wide range of serious diseases. We utilize our proprietary AOC platform to design, engineer and develop therapeutics that combine the tissue selectivity of monoclonal antibodies (mAbs) and the precision of oligonucleotide-based therapies in order to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. We are passionate about the impact of every employee in bringing these potentially transformative therapeutics to patients in need. Make a difference with us.
Job Summary
We are seeking a highly motivated Research Associate I/II to join our biology team responsible for the preclinical development of drug compounds. Successful candidates will bring hands-on experience in rodent disease models, PD, and PK studies. This is a lab-based position primarily performing, hands-on, in vivo studies in rodents, in vitro work, analyzing data, meeting with key stakeholders to present results, and serving as a team representative. The ideal candidate will be proficient in biological and physiological techniques (in vitro and in vivo), precise documentation, demonstrate clear and professional verbal and written communication, and be a strong team player.
Essential Duties and Responsibilities:
- Design and perform experiments (in vitro and in vivo), analyze data, and interpret and report results
- Develop and optimize biochemical, molecular, and cellular biology methods as needed
- Collaborate and communicate with other team members and across departments
- Keep detailed and accurate records, present data in verbal as well as written form
- Work with supervisor to prioritize work
- Provide training to new laboratory staff
- Perform other duties as required
Qualifications:
- B.S./M.S. in Molecular Biology, Physiology, Pharmacology, or related disciplines, 1-2 years of experience in academic labs or in industry
- Prior hands-on experience with in vivo mouse handling and tissue collection
- Experience in rodent echocardiography is a plus
- Prior hands-on lab experience with the following techniques: cell culture, RNA isolation, and qPCR
- Ability to learn and adapt new laboratory techniques and protocols in a fast-changing environment with a diverse team of coworkers
- Familiar with Microsoft Office (Excel, Word, PowerPoint) and GraphPad Prism
- Demonstrated ability to work effectively with little to no supervisio
- High attention to detail in research, reliable, organized, excellent record keeping
- Critical thinking, excellent data analysis and problem-solving skills
- Excellent communication skills
Physical Requirements /Demands:
- Remaining in a stationary position, often standing or sitting for prolonged periods.
- Comfortable working in small rooms with imaging equipment and dimmed lights
- Moving about to accomplish tasks or moving from one station to another, or from one worksite to another.
- Adjusting or moving objects up to 10, 25, 50 pounds.
- Communicating with others to exchange information.
- Repeating motions that may include the wrists, hands and/or legs.
- Repeating motions of fingers (typing and/or writing).
- Operating machinery or equipment. [Computer, laboratory equipment, manual pipettes, copiers, etc.]
- Assessing the accuracy, neatness and thoroughness of the work assigned.
Environmental Conditions:
- Low temperatures.
- High temperatures.
- Noisy environments.
- No adverse environmental conditions expected.
- Exposure to general laboratory environment conditions.